Personalized external aortic root support has completed initial evaluation and has technology appraisal in the UK for patients with Marfan syndrome for use as an alternative to root replacement. Its long-term success in preventing aortic dissection remains uncertain. Here, we report a study in sheep to establish whether the externally supporting mesh, as used clinically, is biologically incorporated. The strength of the resulting mesh/artery composite has been tested.
The carotid artery of growing sheep (n = 6) was enclosed in a mesh sleeve made of a polymer, polyethylene terephthalate. After a predefined interval of 4–6 months, a length of the artery was excised, including the sleeved and unsleeved portions, and was stress tested and examined histologically.